Wilshere tweeted: "Just got home! Had a drugs test so was later than usual! Thought the fans were Amazing from start to finish! Really appreciated! #gooner."
While Arsenal fans congratulated Wilshere on his efforts in the 2-0 loss, abusive web trolls posted sick claims and messages to the midfielder.
The England international had been out with an ankle injury for over a year and it was suggested his absence was down to a failed drugs test.
"Most of the abuse was the kind of stuff he hears on the terraces. But it has got more personal.
"The stuff about the drug test was the final straw — he would never take drugs. It’s upsetting that someone can be so vile."
One troll last night messaged Wilshere: "I’m sure the cocaine trace will still be there.
One wrote: "Cocaine boy! #Positivr" and another added: "drugs test ya may hope all the coke was out of your system."